Randomized controlled trials could be harming nonprofits, experts argue

In the 1940s, medical researchers began using randomized controlled trials to assess the efficacy of health interventions. In ...
Heart

Comprehensive guideline-directed medical therapy strategies on health status outcomes in patients with heart failure: the LAQUA-HF randomised clinical trial

Background Introduction of guideline-directed medical therapy (GDMT) has transformed the care of heart failure (HF) with ...
Medycyna Praktyczna

Efficacy of unilateral laparoscopic-guided abdominal wall block compared to local infiltration in postoperative analgesia following laparoscopic cholecystectomy: a single ...

Introduction: Effective postoperative analgesia is crucial for recovery after laparoscopic cholecystectomy (LC). Although local anaesthetic infiltration (LAI) is commonly used, transversus abdominis ...
STAT

Why Silicon Valley should demand clinical trials for its medical AI

Elemento is the director of the Englander Institute for Precision Medicine at Weill Cornell Medicine. Sternberg is the clinical director of the Englander Institute for Precision Medicine. Khozin is ...
BMJ Open

Family-supported hearing aid use behaviour intervention to improve outcomes in older adults at high risk for dementia (SOUND): study protocol for a randomised co…

Background Hearing loss (HL) imposes a substantial burden on families and society and is the largest modifiable risk factor ...
Lupus Science & Medicine

Can disease activity and treatment responses be captured by a core set of domains in SLE clinical trials? An analysis of phase III belimumab trial data

Objective Outcome measures used in SLE randomised controlled trials (RCTs) have impeded trial success and drug approval. In ...
ascopubs.org

Randomized Controlled Trial of a Virtually Delivered Exercise and Stress Management Program to Improve Physical Performance of Hematopoietic Cell Transplant Survivors

Oxaliplatin-Based Versus Alkylating Agent in Neuroendocrine Tumors According to the O6-Methylguanine-DNA Methyltransferase Status: A Randomized Phase II Study (MGMT-NET) The median time post-HCT was ...
ascopubs.org

A multicenter, randomized, controlled, open-label trial to determine the optimal duration of steroid therapy for mild pneumonitis associated with immune checkpoint inhibitors.

Results of a multisite randomized trial of Bright IDEAS-Young Adults: Efficacy of problem-solving skills training on distress and health-related quality of life. This is an ASCO Meeting Abstract from ...