Complement is a key component of immunity with crucial inflammatory and opsonic properties; inappropriate activation of complement triggers or exacerbates inflammatory disease. Complement ...

The three pathways of activation all generate homologous variants of the protease C3-convertase. The classical complement pathway typically requires antigen—antibody complexes (immune complexes) for ...

The complement system is a critical modulator of immune responses that triages microbial and other threats through pattern recognition, tailored effector functions, and intensive crosstalk with other ...

Panel A shows the profile of autoantibodies binding to factor B, C3b, and C3 activation fragments in Patients 1 and 2. I bars denote the standard deviation of three independent tests. As shown in ...